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大肠直肠癌中的aptasensors:用于精确诊断的新兴工具

Qamar Abuhassan¹, Ali M Atoom², R Roopashree³

¹Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, University of Jordan, Amman, 11942, Jordan.

Clinica chimica acta; international journal of clinical chemistry

|December 6, 2025

概括

纳米材料增强了对结直肠癌 (CRC) 生物标志物的食传感器检测,用于早期诊断. 需要进一步的研究来标准化和临床验证这些先进的生物传感器.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
分析化学分析化学

背景情况:

应用传感器对于结直肠癌 (CRC) 生物标志物检测至关重要.
纳米材料显著提高了食感器的灵敏度,稳定性和信号传导.
现有的适应传感器在临床翻译和标准化方面面临挑战.

研究的目的:

审查各种纳米材料在CRC适应传感器开发中的作用.
分析不同类型纳米材料的优点和局限性.
确定适应传感器临床应用的未来方向.

主要方法:

在CRC适应传感器中纳米材料集成的综合文献综述.
对纳米材料特性 (AuNP,碳基,MOF,COF等) 的分析. 用于生物感知.
对增强检测的DNA放大技术 (HCR,酶循环) 的评估.

主要成果:

黄金纳米粒子 (AuNPs) 提供了多功能平台,但存在可变性问题.
碳纳米材料为检测CEA和CA19-9等CRC标记物提供了出色的导电性.
MOF和COF可以实现多重复合,但面临着稳定性挑战.
DNA放大技术可以达到高灵敏度,但对于在医院使用而言是复杂的.

结论:

纳米材料增强的食感传感器显示出早期CRC诊断的前景.
在标准化,可扩展性和临床验证方面存在关键差距.
未来的工作应该专注于用于现实世界的应用程序的简化,可重复的设计.

关键词:

适用于传感器.结肠直肠癌的生物标志物 DNA信号放大 DNA信号放大黄金纳米颗粒的使用方法纳米材料是一种纳米材料.

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