通过调节肠道微生物群和胆酸代谢,D-粉可缓解DSS诱导的结肠炎
Gaoqi Ye1, Na Xi2, Genying Li2
1Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University), Ministry of Education, Beijing 100048, China; Key Laboratory of Food Nutrition and Health Evaluation Technology, State Administration for Market Regulation, Beijing 100048, China.
在小鼠模型中,D-allulose补充剂显著降低了性结肠炎的症状. 低剂量的D-粉恢复了肠道屏障功能,调节了肠道微生物群和胆酸代谢,表明其作为功能性食物的潜力.
科学领域:
- 胃肠病学和营养科学 胃肠病学和营养科学
- 免疫学和微生物学
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,治疗选择有限.
- 一种罕见的单糖体D-粉素具有已知的生物功能,但其在UC中的作用尚不清楚.
研究的目的:
- 为了研究D-allulose对硫酸 (DSS) 诱导的大肠炎的治疗作用.
- 为了阐明D-allulose在结肠炎中的作用的潜在机制.
主要方法:
- 给患有DSS诱导的大肠炎的小鼠服用不同剂量的D-allulose.
- 评估临床结肠炎症状,结肠组织学,肠道屏障标记物,炎症标记物,肠道微生物群组成和代谢学 (胆酸概况).
主要成果:
- D-allulose显著改善了结肠炎症状和结肠损伤.
- 它通过调节紧密结合蛋白和粘膜来恢复肠道屏障的完整性.
- D-allulose减少了炎症细胞的透和促炎性细胞因子的表达.
- 低剂量D-素 (125 mg/kg) 显示出最显著的保护作用.
- 它通过TGR5-PKA-NF-κB通路调节了肠道微生物组成和胆酸代谢.
结论:
- 在治疗性结肠炎方面,D-allulose具有显著的治疗潜力.
- 它的有效性与恢复肠道屏障功能,调节炎症以及影响肠道微生物群和胆汁酸代谢有关.
- 作为炎症性肠道疾病的功能性食品成分,D-氨酸表现有前途.
相关概念视频
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Drugs for Treatment of Ulcerative Colitis in IBD
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Drugs Affecting GI Tract Motility: Other Laxatives
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
Adsorbents...


