MAAD:多维抗病毒抗体数据库

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Yixin Li^1,2,3, Jinyue Wang^1,2,3, Chuziyue Zhang^1,2,4

¹State Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

|December 6, 2025

概括

多维抗病毒抗体数据库 (MAAD) 提供了一个标准化的平台,用于探索抗体序列,结构和功能. 该资源有助于比较抗病毒研究和治疗抗体的合理设计.

科学领域:

免疫学和病毒学
生物信息学和计算生物学
药物发现和开发药物发现和开发

背景情况:

抗体对于预防和治疗病毒感染至关重要.
目前的抗体发现正在从查转向理性设计,需要集成的序列结构功能数据.
现有的资源缺乏对抗病毒抗体的标准化和全面的多维特征.

研究的目的:

引入多维抗病毒抗体数据库 (MAAD) 作为一个标准化,精心策划的资源.
整合针对高影响RNA病毒的抗体的多维特征.
为了促进系统的探索,跨病原体比较和合理的抗体设计.

主要方法:

开发了MAAD数据库,该数据库专注于冠状病毒,甲状腺病毒和肺炎病毒.
集成的交互式分析模块用于CDR/生殖系注释,序列分析,聚类和接口残留物识别.
包括每站点和突变速率概况,用于深入的序列特征探索.

主要成果:

MAAD提供了一个全面的,精心策划的抗病毒抗体,纳米体和单链变量片段数据集.
交互式模块可以对抗体序列,结构和功能关系进行详细分析.
该平台支持以结构为导向的关键抗体残留物和突变配置文件的识别.

结论:

MAAD 桥梁抗体序列,结构和功能,用于先进的研究.
该数据库为比较抗病毒研究提供了一个开放和标准化的平台.
MAAD显著支持和推进治疗抗体的发现和合理设计.

关键词:

的RNA病毒RNA病毒.抗体数据库中的抗体.有理性的抗体设计.序列-结构-功能集成.

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相关概念视频

Antibody Structure and Classes

Antibody Structure and Classes

Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.