治疗与药物相关的骨瘤的臭氧疗法:一个范围审查
Miguel Ruiz Rincón1, Jorge Cortés-Bretón Brinkmann2, Marko Granić3
1Department of Dental Clinical Specialties, Faculty of Dentistry, Complutense University of Madrid, Madrid, Spain.
Oral surgery, oral medicine, oral pathology and oral radiology
|December 6, 2025
概括
臭氧疗法在治疗与药物相关的下骨硬化 (MRONJ) 中表现有前途. 研究表明有显著的愈合率,但需要更多的研究来证实它的有效性.
科学领域:
- 在口腔外科手术中.
- 牙周病学 牙周病学
- 生物医学工程 生物医学工程
背景情况:
- 与药物相关的下骨硬化 (MRONJ) 是一个重大的临床挑战.
- 目前对MRONJ的管理策略存在局限性.
研究的目的:
- 系统地审查有关臭氧治疗的文献,以对MRONJ进行管理.
- 评估臭氧治疗在MRONJ病例中的疗效和结果.
主要方法:
- 在多个数据库中进行了全面的电子文献搜索.
- 提取了患者人口统计,MRONJ特征,臭氧治疗方案和结果的数据.
- 研究协议在开放科学框架 (OSF) 上注册.
主要成果:
- 包括14项涉及191名患者和197名MRONJ病变的研究.
- 臭氧治疗方案和辅助治疗有很大的差异.
- 在大约72%的患者和病变中报告了完全的粘膜愈合和症状消失.
结论:
- 臭氧治疗显示出作为MRONJ的辅助治疗的潜力,由于其抗微生物,抗炎和再生性质.
- 进一步高质量的临床试验与标准化方案是必要的,以验证其疗效和临床实用性.
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