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突关节功能障碍的关节内疗法:综合综合性综述
Leonardo Brigido Metello Neves1, Bernardo Correia Lima2, Rafael Coutinho de Mello3
1Orofacial Pain, Estacio de Sá University, Rio de Janeiro RJ, Brazil.
Oral surgery, oral medicine, oral pathology and oral radiology
|December 6, 2025
概括
像介质干细胞和可注射的富含血小板纤维素等再生疗法对关节 (TMJ) 骨关节炎有希望. 氨酸仍然是缓解疼痛和滑关节的安全选择.
科学领域:
- 整形外科和再生医学
- 口腔和牙面部外科手术
- 生物材料科学 生物材料科学
背景情况:
- 突关节功能障碍,特别是关节骨关节炎 (TMJ),是一个重大的临床挑战.
- 目前的治疗模式从息措施到更先进的再生方法.
研究的目的:
- 综合当前关于协关节疾病的关节内疗法的证据,重点关注TMJ骨关节炎.
- 评估再生,滑,抗炎和辅助/组合疗法.
主要方法:
- 2020年至2025年间发表的综合性叙事综述研究.
- 包括来自主要数据库的随机试验,系统评论,元分析和临床前研究.
- 优先考虑关节特异性的数据,并在适用时从其他突关节进行推断.
主要成果:
- 介质干细胞显示显著减少疼痛和功能改善,具有良好的安全性.
- 可注射的富血小板纤维素 (i-PRF) 显示持续的生物活性释放,调节炎性细胞因子,并促进了冠状体的保存.
- 氨酸 (HA) 提供了一致的疼痛缓解与卓越的安全性,而皮质类固醇提供了短期的好处与chondrotoxic风险.
- 辅助疗法和组合疗法显示出有希望的结果.
结论:
- 关节内疗法正在向机制驱动的疾病调制发展.
- 介酶干细胞和i-PRF具有强大的疾病修饰潜力,HA作为基础治疗.
- 准备和报告的标准化,以及专门的TMJ临床试验,对于推进治疗至关重要.
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