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孕产妇的饮食塑造了组织居民巨细胞的发展和身份

Hao Huang¹, Elvira Mass¹

¹Developmental Biology of the Immune System, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.

Trends in immunology

|December 6, 2025

概括

早期发育期间的孕产妇营养不良组织寄存巨细胞 (TRMs),影响后代的疾病风险. 这些编程的TRM将孕产妇的营养与持久的健康结果联系起来,提供潜在的干预目标.

科学领域:

发育生物学是发展生物学.
免疫学免疫学免疫学
营养科学营养科学

背景情况:

健康和疾病的发育起源 (DOHaD) 概念强调了影响以后健康的早期环境暴露.
孕产妇营养不良是影响后代健康轨迹的重要因素.
组织寄存巨细胞 (TRMs) 是居住在组织中的免疫细胞,从胚胎形成开始就存在,并在整个生命中持续存在.

研究的目的:

提出组织寄居巨细胞 (TRMs) 作为由于母亲营养不良而导致的发育编程中的中心调解者.
探索母亲的饮食如何编程不同的TRM子集.
了解编程TRMs与后代疾病易感性之间的联系.

主要方法:

这项研究是一项综述和概念性建议,总结了有关DOHaD,孕产妇营养和TRMs的现有研究.
它整合了关于TRM在胚胎发生过程中如何播种和响应代谢和激素信号的发现.
作者讨论了TRM如何将母亲的营养状态编码为持久的组织适应.

主要成果:

孕产妇营养不良永久改变后代的细胞和组织功能.
特定的孕产妇饮食可以编程TRMs的不同的子集.
编程的TRM是母亲的营养状况和后代的疾病易感性之间的关键联系.

结论:

组织寄存型巨细胞 (TRMs) 被认为是孕产妇营养不良引发的发育编程的关键调解者.
编程的TRM可以建立持久的组织适应,从而影响后代的健康.
对于改善后代健康结果的早期干预来说,TRMs是一个有希望的目标.

关键词:

发展规划是指发展规划.巨细胞是一个巨细胞.营养不良营养不良营养不良孕产妇和胎儿之间的轴线.营养营养营养营养过度营养营养过多

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