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Updated: Jan 9, 2026

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暂时解决和可解释的机器学习模型的GPCR合规过渡

Babgen Manookian1, Elizaveta Mukhaleva1,2, Grigoriy Gogoshin1

  • 1Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA.

Nature communications
|December 6, 2025
PubMed
概括

为多巴胺受体D2R和D3R开发特定亚型药物是一项挑战. 我们的新DRUMBEAT算法识别了对D3R形状变化至关重要的独特的残留群体,帮助针对神经系统疾病的向药物设计.

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