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跨人群前列腺癌风险的全蛋白质组关联研究

Hua Zhong^1,2, Jingjing Zhu^2,3, Shuai Liu^1,2

¹Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawai'i Cancer Center, University of Hawai'i at Mānoa, Honolulu, HI, USA.

Nature communications

|December 6, 2025

概括

这项研究使用全蛋白质组关联研究 (PWAS) 在不同人群中确定了与前列腺癌 (PCa) 风险相关的蛋白质. 研究结果揭示了普世性和人群特异性的蛋白质关联,进步了对PCa病因学的理解.

科学领域:

遗传学和基因组学遗传学和基因组学
在瘤学瘤学.
蛋白质组学是指蛋白质组学.

背景情况:

前列腺癌 (PCa) 的分子基础在不同的全球人口中有很大差异.
了解这些人群特异性的分子差异对于推进PCa研究和治疗至关重要.

研究的目的:

进行一项大规模的全蛋白质组关联研究 (PWAS),以确定与PCa风险相关的蛋白质.
研究非洲,欧洲,亚洲和西班牙裔/拉丁裔人口的血中基因调节蛋白质表达.
为了发现全种群和特定种群的蛋白质与PCa的关联.

主要方法:

为四个不同的种族群体在血中表达数千种蛋白质开发了基因预测模型.
评估了基因调节蛋白表达和PCa风险之间的关联,使用跨种群的大型病例对照队列.
进行跨种群元分析以确定共享的遗传关联.

主要成果:

确定了大量的PCa相关蛋白质,欧洲人群中有73种,亚洲人群中有15种,西班牙裔/拉丁裔人群中有4种,非洲人群中有3种.
通过跨人群元分析发现了83种PCa相关蛋白质.
证实了PCa风险的共同 (全人口) 和独特 (人口特异) 蛋白质关联的存在.

结论:

该研究成功地确定了与前列腺癌风险相关的许多蛋白质,突出了血蛋白表达的遗传调节.
这些发现强调了在PCa研究中考虑人口多样性的重要性.
这些见解为跨越不同祖先的前列腺癌的病因学理解提供了宝贵的知识.

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