电 ?? 疗法通过促进周神经元净降解来促进远程恐惧记忆的擦除
Shuai-Wen Teng1,2, Wen-Bo Guo2, Bing-Feng Song1
1Department of Anatomy and Neurobiology, Shandong Key Laboratory of Mental Disorders and Intelligent Control, School of Basic Medical Sciences and Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P.R. China.
Translational psychiatry
|December 6, 2025
概括
由于周神经网络 (PNN),远程病理记忆是刚性的. 电针 (EA) 降解PNN,使得通过后检索灭绝可以消除记忆,提供了一种新的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 记忆研究 记忆研究
- 治疗干预 治疗干预
背景情况:
- 恢复后的灭绝有效地删除了最近的病态记忆.
- 遥远的病理记忆无法被删除,这构成了重大的治疗挑战.
- 脑前皮层 (PrL) 中的Engram细胞周围的周围神经网络 (PNNs) 随着记忆的远距离而增加,可能会使这些记忆变硬.
研究的目的:
- 调查PNN在远程病理记忆的持久性中的作用.
- 探索消除远程病态记忆的方法.
- 评估电针 (EA) 作为一种非侵入性治疗策略,用于远程删除记忆.
主要方法:
- 识别了远程记忆的PrL中engram细胞周围增加的PNN.
- 将ChABC直接微注射到PrL中,在恢复后的灭绝过程中降解PNN.
- 在Baihui (GV20) 和Neiguan (PC 6) 应用EA.
- 在PrL中评估PNN降解,MMP-9表达,BDNF-TrkB信号传递和神经元活动重叠 (恐惧和灭绝细胞).
主要成果:
- 在PrL的远程记忆engram细胞周围观察到PNN的增加.
- 通过降解PNN,ChABC微注射促进了远程记忆的删除.
- 在PrL中,EA治疗通过通过BDNF-TrkB信号传递对神经元MMP-9进行上调来降解PNN.
- EA刺激促进了远程删除记忆,并增加了PrL中的恐惧和灭绝细胞之间的重叠.
结论:
- 围绕恩格拉姆细胞的PNN在防止远程记忆被删除方面发挥着至关重要的作用.
- 电子记忆是一种可行的非侵入性方法,可以促进远程的病理性记忆除.
- EA的机制涉及PNN降解,可能为与记忆有关的疾病提供新的治疗途径.
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