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辅助生殖技术中的子宫和阴道微生物组:对母亲和后代的结果的影响

Zainab Yusufali Motiwala¹, Sidharth Misra², Ishika Sharma³

¹JNMCH, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Journal of assisted reproduction and genetics

|December 6, 2025

概括

辅助生殖技术 (ART) 可以破坏生殖道微生物群,导致不良的怀孕和后代结果. 了解和恢复微生物组是改善ART成功和母胎健康的关键.

科学领域:

生殖医学生殖医学
微生物组研究微生物组研究
产科和妇科产科和妇科

背景情况:

辅助生殖技术 (ART) 已经推进了不孕症治疗,但与增加母亲和后代风险有关.
生殖道微生物群,特别是阴道和子宫内膜,在植入和怀孕中起着至关重要的作用.
对这种微生物群的破坏越来越被认为是ART结果的一个因素.

研究的目的:

在ART的背景下,审查关于子宫和阴道微生物组的当前知识.
检查ART程序如何影响微生物组的组成和功能.
探索微生物组改变对母亲健康,怀孕和后代发育的影响.

主要方法:

2005年至2025年间出版的文学作品的叙事综合.
在PubMed,Scopus和CINAHL数据库中进行的搜索.
包括专注于与ART相关的微生物组变化和生殖结果的文章.

主要成果:

ART干预措施 (例如,消毒剂,激素刺激,抗生素) 破坏生殖微生物群,减少Lactobacillus和促进失生症.
微生物组失调与更低的植入率,更高的妊娠障碍 (孕,妊娠糖尿病),早产和不良新生儿结果有关.
益生菌和多原子平台等新兴策略显示出潜力,但需要进一步的临床验证.

结论:

子宫和阴道微生物组通过影响植入,免疫耐受性和胎儿发育来显著影响ART的成功.
个性化微生物组诊断和治疗是精确生殖医学的一个有希望的途径.

关键词:

辅助生殖技术是一种辅助生殖技术.失生症是一种失生症.宫内膜的微生物群.植入植入植入植入植入植入植入植入婴儿健康婴儿健康母亲的结果.微生物组诊断的方法益生菌益生菌益生菌阴道的微生物组.

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