精神分裂症患者的丘脑的两个结构变化模式
Wei Yu1,2,3, Qiannan Zhao1,2,3, Bo Tao1,2,3
1Department of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, West China Hospital of Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, China.
精神分裂症患者表现出两种不同的thalamic亚型:一种是渐进的体积损失,可能受益于早期干预,另一种是随着时间的推移而变化的体积增加.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 大脑解剖学 大脑解剖学
背景情况:
- 精神分裂症与胸膜结构障碍有关.
- 以前的研究表明,精神分裂症的体内有异质性.
- 精神分裂症的thalamic核亚型之间的变化模式仍然不清楚.
研究的目的:
- 在精神分裂症中识别出不同的神经解剖学体亚型.
- 调查这些亚型在第一次发作和长期疾病中的进展.
- 为了验证机器学习分类器用于亚型识别.
主要方法:
- 在124名以前没有服用过药物的第一发精神分裂症 (FES) 患者中,K-means对thalamic核体积的集群分析.
- 在独立的FES和长期精神分裂症队伍中开发和验证机器学习分类器.
- 对规范性大脑结构和认知数据与对照组进行比较.
主要成果:
- 在FES中确定了两种可复制的胸膜亚型:亚型1 (广泛的体积减少) 和亚型2 (广泛的体积增加).
- 第1亚型在长期治疗的患者中显示出更严重的缺陷和认知异常.
- 亚型2在接受治疗的患者中显示出特定核的减弱增加,而在从未接受治疗的患者中没有显著变化.
结论:
- 在精神分裂症中存在两种神经解剖学体亚型.
- 1亚型,呈现渐进的缺陷,可能需要早期检测和认知干预.
- 亚型2的独特病理生理学可能与治疗或疾病的过程有关,这需要进一步的纵向研究.
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