在美国成年人中,睡眠障碍与类风湿性关节炎之间的关联
Liujie Zheng1, Guoqiang Li1, Zhiyong Hou2,3,4,5
1Department of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, 050051, Hebei, China.
Arthritis research & therapy
|December 6, 2025
概括
睡眠障碍与美国成年人患类风湿性关节炎 (RA) 的可能性更高有关. 这项研究突出显示了显著的关联,尽管因果关系需要进一步调查.
科学领域:
- 类风湿病学 类风湿病学
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 关于睡眠障碍与类风湿性关节炎 (RA) 之间的联系的证据有限.
- 这项研究使用来自美国国家健康和营养检查调查 (NHANES) 的美国成年人数据调查了这种关联.
研究的目的:
- 检查睡眠障碍与类风湿性关节炎在美国大量成年人群中的患病率之间的关系.
- 通过使用国家调查数据,识别睡眠障碍和RA之间的潜在联系.
主要方法:
- 从NHANES (2005-2018) 对28040名美国成年人 (≥18岁) 的横截面分析.
- 使用加权的多变量逻辑回归模型来评估睡眠障碍和RA之间的关联.
- 分析包括未调整,最小调整 (人口统计学) 和完全调整 (生活方式,临床因素) 的模型,以及子组和灵敏度分析.
主要成果:
- 14.32%的参与者报告睡眠障碍,4.28%的人报告RA.
- 在完全调整的模型中,睡眠障碍与RA的几率增加显著相关 (OR=1.76,95% CI:1.46-2.13).
- 睡眠障碍和RA之间的积极关联在所有子组中都是一致的.
结论:
- 在美国成年人中,睡眠障碍和类风湿性关节炎患病率之间存在统计学意义上的关联.
- 截面设计排除了因果推理;需要进一步的纵向和机理学研究.
- 未来的研究应该探索睡眠障碍和RA之间的时间关系和生物学机制.
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