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流行病学和转录组数据确定了参与糖尿病病炎症反应的潜在关键基因

Shan He¹, Yiwei Chen², Jian Ye¹

¹Department of Nephrology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Scientific reports

|December 6, 2025

概括

中性粒细胞百分比与白蛋白比率 (NPAR) 是糖尿病病 (DN) 风险的重要指标. 对DN的新见解

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
免疫学免疫学免疫学
遗传学遗传学是一个

背景情况:

糖尿病病 (DN) 是糖尿病的一种严重并发症,与炎症过程有关.
中性粒细胞百分比与白蛋白比率 (NPAR) 是一个新兴的炎症标志物.

研究的目的:

为了调查NPAR和DN风险之间的关联.
探索DN开发中潜在的分子机制和潜在的治疗点.

主要方法:

分析国家健康和营养检查调查 (NHANES) 数据 (2009-2018) 的流行病学关联.
对基因表达总体 (GEO) 转录组数据的生物信息分析,以识别枢纽基因和通路.
多变量线性回归和子组分析,以评估NPAR与DN的关联.

主要成果:

在NPAR和DN风险之间发现了显著的积极关联 (OR 1.62-2.06).
这种关联在各种人口和临床子组中是一致的.
生物信息学确定了49个枢纽基因,包括DUSP1,CXCR1和SKIL,p38MAPK通路在DN中发挥着中心作用.
ресвератрол,库尔库明和热尼斯坦与关键基因 (DUSP1,CXCR1,SKIL) 产生强烈的相互作用,这表明它们具有治疗潜力.

结论:

NPAR是DN的可靠诊断指标.
炎症反应显著影响DN的发展和进展.
ресвератрол,黄素和热尼斯作为DN的潜在治疗剂具有前景.

关键词:

生物信息学分析糖尿病脏病糖尿病脏病药物目标是药物目标.炎症反应是一种炎症反应.中性粒细胞百分比与白蛋白的比率.

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