内皮激活和压力指数与老年人认知功能的关联:与机器学习的横截面研究
Zixu Wang1, Yin Liu1, Zhiliang Zhou2
1Tianjin University of Traditional Chinese Medicine, Tianjin, China.
European journal of medical research
|December 6, 2025
概括
内皮激活和压力指数 (EASIX) 与老年人的认知功能较差有关. 较高的EASIX分数与认知能力下降相关,这表明它有可能成为认知能力下降的生物标志物.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 心血管研究研究心血管研究
背景情况:
- 年龄相关记忆障碍 (AAMI) 是一种与内皮功能障碍相关的先发性精神状态.
- 内皮激活和压力指数 (EASIX) 量化了内皮损伤,但缺乏关于认知功能的人口研究的验证.
- 这项研究研究了EASIX与老年人认知表现之间的关系.
研究的目的:
- 评估60岁及以上成年人内皮激活和压力指数 (EASIX) 与认知表现之间的关联.
- 确定EASIX是否可以作为早期认知衰退的潜在生物标志物.
主要方法:
- 分析了来自NHANES 2011-2014年2,763名年龄≥60岁的成年人的数据.
- 用多重线性回归和LASSO回归来进行变量选择.
- 开发和评估了六个机器学习模型,包括随机森林和XGBoost,用于特征重要性分析的SHAP值.
主要成果:
- 在EASIX和所有认知分数之间观察到显著的负相关性 (P <0.05).
- 弹性网模型在预测认知功能方面表现出卓越的表现.
- SHAP分析发现EASIX是关键的影响变量,显示认知能力下降趋势与EASIX分数的增加,特别是在老年人中.
结论:
- 内皮激活和压力指数 (EASIX) 与认知功能有显著的负相关性,特别是在晚年.
- 虽然横截面设计限制了因果推断,但EASIX显示出作为血液基生物标志物的前景,用于早期查和认知衰退风险评估.
- 这些发现支持EASIX在识别面临认知障碍风险的个体方面的潜在临床实用性.
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