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Updated: Jan 7, 2026

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天生的免疫细胞衍生BAFF通过非正规NF-κB在糖尿病自身免疫中促进ICOSL+B细胞的炎症反应

Zeying Li1, Mingjiu Zhao2, Wenjun Luo2

  • 1National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China; Department of Endocrinology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China; CSU-Sinocare Research Center for Nutrition and Metabolic Health, Xiangya School of Public Health, Central South University, Changsha, China; Furong Laboratory, Changsha, China.

Molecular therapy : the journal of the American Society of Gene Therapy
|December 7, 2025
PubMed
概括

研究人员发现了一种特定的B细胞子集,ICOSL+B细胞,驱动1型糖尿病 (T1D) 的进展. 阻止这种途径改善了小鼠模型中的自身免疫性疾病,为T1D提供了新的治疗点.

关键词:
B细胞激活因子激活因子B 细胞 B 细胞巴夫 (BAFF) 是一个巴夫.在ICOSL中,ICOSL是指ICOSL.这是自身免疫力.免疫检查点的检查点.可诱导的T细胞共刺激器连接体.第1类糖尿病 1型糖尿病

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