在艾滋病毒感染者中接种乙型肝炎病毒疫苗:有什么新鲜事?
Fiona Gispen1, Anne F Luetkemeyer2, Kristen M Marks1
1Division of Infectious Diseases, Weill Cornell Medicine, New York, New York.
Current opinion in HIV and AIDS
|December 7, 2025
概括
在感染艾滋病毒 (PWH) 的人群中,乙型肝炎病毒 (HBV) 疫苗接种至关重要. 新的HepB-CpG疫苗提供了卓越的保护和耐用性,解决了PWH的历史限制.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 乙型肝炎病毒 (HBV) 疫苗接种覆盖率在艾滋病毒感染者 (PWH) 中较低.
- 以前的HBV疫苗在PWH中表现出有限的有效性,原因是免疫反应不佳和免疫力下降.
- 不断发展的抗逆转录病毒疗法 (ART) 策略为HPH的HBV预防带来了新的挑战.
研究的目的:
- 审查最近HBV疫苗接种策略的进展.
- 要总结HBV疫苗接种在这个人群中的最新指导方针.
- 讨论与新型ARTs和疫苗犹相关的新兴风险.
主要方法:
- 关于在PWH中接种HBV疫苗的最近研究的文献综述.
- 分析最新的临床指南和建议.
- 评估HBV预防中新出现的风险和挑战.
主要成果:
- 在HBV疫苗接种后,PWH表现出降低的免疫性和更快的抗体衰退.
- 添加剂的HepB-CpG疫苗在PWH中显示出卓越的血清保护和耐用性.
- 更新的指导方针现在支持HepB-CpG作为PWH的首选疫苗.
结论:
- 接种HBV疫苗对于预防HBV感染和PWH的发病率至关重要.
- 广泛采用HepB-CpG疫苗,血清学监测和主动疫苗接种是关键.
- 这些策略支持HBV消除努力,特别是随着ART景观的变化.
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