相关实验视频

Updated: Jan 9, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

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降解剂-药物合物 (DDC) 中介免疫化学疗法用于瘤治疗

Bichun Chen1,2, Jinyu Bai1, Huaihuai Shi1

  • 1Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, Key Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, State Key Laboratory of Biomedical Imaging Science and System, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Journal of medicinal chemistry
|December 7, 2025
PubMed
概括

这项研究引入了一种新的降解剂-药物结合物 (DDC),降解PD-L1并将细胞毒剂传递给瘤细胞. 这种双重作用的方法通过将免疫激活与直接杀死细胞相结合,提高了抗瘤疗效.

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Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting11:58

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