圣神经刺激和慢性膀疼痛:元分析
Rodwan Husein1, Moein Tavakkoli2, Sara Ahmadi Abhari3
1University College London Hospitals, London, UK; Cleveland Clinic London, London, UK.
概括
在慢性膀疼痛综合征 (CBPS) 患者中,神经神经刺激 (SNS) 显著减少了疼痛和尿路症状. 然而,由于研究的局限性,需要更多高质量的试验.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 疼痛管理 疼痛管理
- 神经调节是一种神经调节.
背景情况:
- 慢性膀疼痛综合征 (CBPS) 由于治疗疗效有限,存在重大挑战.
- 圣神经刺激 (SNS) 是一种新兴的治疗方法,用于耐火性下泌尿道症状和盆腔疼痛.
研究的目的:
- 评估圣神经刺激 (SNS) 治疗慢性膀疼痛综合征 (CBPS) 患者疼痛,尿道症状和生活质量 (QoL) 的有效性.
主要方法:
- 使用EMBASE,PubMed和Cochrane图书馆进行了对15项研究 (N=494) 的系统审查和元分析.
- 包括的研究集中在接受SNS治疗的成年CBPS患者身上,测量疼痛评分,间歇性囊炎症状指数 (ICSI),尿动频率,夜尿和QOL.
- 评估了偏差风险,并使用随机效应元分析模型计算了聚合效应估计.
主要成果:
- SNS显示疼痛得分 (平均差异: -2.27),ICSI (-2.18),尿动频率 (-1.71次/天) 和夜尿 (-1.49次/晚) 的统计学显著减少.
- 没有观察到间歇性囊炎问题指数 (ICPI) 或生活质量 (QoL) 的显著变化.
- 并发症的发病率从0%到40.6%不等,发病率在0%到18%之间.
结论:
- 圣神经刺激 (SNS) 可能为慢性膀疼痛综合征 (CBPS) 患者提供有意义的疼痛和尿路症状缓解.
- 当前研究中的方法异质性和偏差风险限制了最终的结论.
- 为了验证SNS对CBPS治疗的有效性,需要进行更大规模,高质量的随机对照试验,并提供标准化结果.
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