系统性LH度是否会影响被编程的单子冷胚胎转移周期中的活产率?
Laura Marqueta1, Barbara Lawrenz2, Erkan Kalafat3
1ART Fertility Clinics, Abu Dhabi, United Arab Emirates.
Reproductive biomedicine online
|December 7, 2025
概括
孕激素治疗前的全身质化激素 (LH) 水平不会影响在编程单个欧普洛伊德冷胚胎移植 (seFET) 周期中的活产率. 这一发现表明,LH监测对于优化seFET结果可能并不至关重要.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精过程中受精.
- 临床胚胎学 临床胚胎学
背景情况:
- 编程冷胚胎移植协议通常使用激素制剂.
- 黄素激素 (LH) 在规划周期的黄素阶段的作用尚未完全理解.
- 优化活产率 (LBR) 在单个胚胎转移 (seFET) 周期中是辅助生殖技术的一个关键目标.
研究的目的:
- 在编程的seFET循环中调查系统LH度和LBR之间的关联.
- 为了确定孕激素注射前的LH水平是否会影响怀孕结果.
主要方法:
- 758个编程的seFET周期的回顾性队列研究.
- 在准备阶段进行的荷尔蒙分析 (雌激醇,孕,LH).
- 根据LH度百分位数分层的患者.
- 统计分析以评估LH对LBR的影响.
主要成果:
- 总体而言,LBR为48.7%. 这是48.7%.
- 不同的LH百分位组之间没有观察到LBR的显著差异.
- 无论是LH度还是孕激素注射前的斜率都没有与LBR有显著的关联.
- 较差的胚胎质量,较晚的活检日和更高的BMI与负面的妊娠结果有关.
结论:
- 在注射阴道孕激素之前的全身LH度在编程的seFET周期中不会影响LBR.
- 目前的证据不支持常规LH监测,以优化这些特定周期的结果.
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