图像中PET数据的同时减弱和散射校正:图像对图像深度学习模型的定量和临床评估
Avishan Elkayee Dehno1, Pardis Ghafarian2, Hossein Arabi3
1Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Molecular and Cellular Imaging (RCMCI), Advanced Medical Technologies and Equipment Institute (AMTEI), Tehran University of Medical Sciences, Tehran, Iran.
概括
深度学习模型,UNET和CGAN,可以将非衰减分散校正 (NASC) 大脑PET/CT图像转换为测量衰减和分散校正 (MASC) 图像. 这种方法对脑PET成像具有前景,特别是当CT无法使用时.
科学领域:
- 医疗成像医学成像
- 人工智能的人工智能
- 放射学 放射学是一门学科.
背景情况:
- 定子发射断层扫描 (PET) 提供非侵入性代谢评估,但需要对光子衰减和散射进行校正.
- 准确的图像重建对于可靠的PET数据解释至关重要.
研究的目的:
- 开发和评估深度学习算法,用于将无衰减分散校正 (NASC) 大脑PET/CT图像转换为测量衰减和分散校正 (MASC) 图像.
- 评估深度学习在脑PET成像中直接减弱和分散校正的可行性.
主要方法:
- 利用了125名患者的大脑PET/CT (18F-FDG) 数据集.
- 实现了两个卷积神经网络,UNET和CGAN,从2D NASC输入生成MASC图像.
- 进行了定量分析,包括大脑区域细分,放射性特征提取和配对的t测试,以及核医学医生的临床评估.
主要成果:
- 无论是CGAN还是UNET模型,都实现了高图像质量指标 (例如PSNR,SSIM),并在83个大脑区域中保留了放射性特征.
- CGAN模型:PSNR 41.55dB,SSIM 0.997,RMSE 294.8 Bq/ml. 这是一个很大的问题.
- 联合国网络模型:PSNR 40.70 dB,SSIM 0.996,RMSE 327.6 Bq/ml. 这是一个很好的方法. 在放射性特征中观察到最小的显著差异.
结论:
- 卷积深度网络为脑PET成像中的直接衰减和散射校正提供了一个有前途的方法.
- 这种方法在CT数据无法用于传统校正方法的场景中特别有价值.
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