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长非编码RNAJPX:染色体架构中的结构,功能和作用

Arseniy V Selivanovskiy^1,2,3, Anastasiia L Sivkina¹, Sergei V Ulianov^1,2

¹Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia.

Biochemistry. Biokhimiia

|December 7, 2025

概括

长非编码RNAJPX调节基因转录和翻译. 这篇评论详细介绍了JPX的结构,进化和在细胞过程和疾病中的作用.

科学领域:

分子生物学分子生物学
遗传学是一个遗传学.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

长非编码RNAs (lncRNAs) 是细胞过程和疾病生物标志物的关键调节者.
lncRNA JPX涉及转录,翻译和染色体结构.
JPX与CTCF等DNA结合蛋白相互作用,并影响增强剂-促进剂通信.

研究的目的:

审查 lncRNA JPX 的结构,进化起源和功能.
总结JPX在正常细胞功能和病理条件中的作用.
为了突出JPX的多功能监管活动.

主要方法:

文献综述和对JPX现有研究的综合.
对JPX与蛋白质 (例如CTCF) 和核酸 (例如microRNA,mRNA) 的相互作用进行分析.
检查JPX参与转录和翻译监管的情况.

主要成果:

JPX通过影响蛋白质与DNA结合和增强剂-促进剂通信来调节转录.
JPX通过与microRNAs,抑制剂和mRNA稳定剂的相互作用来调节翻译.
JPX在瘤和其他疾病的发病过程中发挥着作用.

结论:

JPX是一种多功能lncRNA,在基因调节和细胞平衡中起着关键作用.
了解JPX的功能,可以了解疾病机制和潜在的治疗点.
对JPX的结构,演变和监管网络进行进一步研究是有必要的.

关键词:

在X染色体不活化过程中,在这种情况下,染色染色素调节基因表达调节基因表达在 lncRNA 中,转录条例转录条例转录条例转录条例翻译法规翻译法规

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