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三种哺乳动物VDAC异型明显调节线粒体功能和蛋白质组,以维持细胞代谢

Megha Rajendran1, William M Rosencrans2, Nina A Bautista1

  • 1Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, USA.

The Journal of biological chemistry
|December 7, 2025
PubMed
概括

电压依赖性离子通道 (VDAC) 异型在细胞代谢中具有不同的作用. VDAC3 KO将线粒体转移到对谷氨酸的依赖,而VDAC1和VDAC2 KO则分别影响糖解和电子运输链组件.

关键词:
在CRISPR/Cas9基因中,基因被淘汰.代谢调节 代谢调节线粒体呼吸链复合体是线粒体呼吸链复合体蛋白质组学 蛋白质组学电压依赖的离子通道.

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