对于ERCP后胰腺炎的预防而使用直肠印梅他辛和迪克洛菲纳克的比较:一项单中心研究
Hüseyin Köseoğlu1, Berkant Bebek2, Tolga Düzenli1
1Hitit University Faculty of Medicine, Department of Gastroenterology, Türkiye.
Clinics and research in hepatology and gastroenterology
|December 7, 2025
概括
在预防ERCP后胰腺炎 (PEP) 方面,直肠迪克洛菲纳克可能比印米他辛更有效,特别是在接受缩切除术的患者中. 这一发现为管理ERCP程序中这种常见的复杂性提供了新的见解.
科学领域:
- 胃肠病学 胃肠病学
- 临床药理学 临床药理学
背景情况:
- 在ERCP后的胰腺炎 (PEP) 是内镜逆向胆血管瘤造影 (ERCP) 的显著并发症.
- 像狄克洛菲纳克和印莫他辛这样的直肠非类固醇抗炎药 (NSAIDs) 可以减少PEP的发生率.
- 有限的现实世界数据存在,比较直肠狄克洛菲纳克和印米他辛的疗效.
研究的目的:
- 为了比较直肠迪克洛菲纳克与印米他辛在预防PEP方面的疗效.
- 为了确定受益于特定NSAIDs用于PEP预防的患者子组.
主要方法:
- 对767名接受ERCP的患者进行了回顾性观察性研究.
- 在接受直肠印莫他辛 (322) 与迪克洛芬雅克 (445) 的患者中比较PEP发病率.
- 分析了二次结果,并根据临床风险因素进行了子组分析.
主要成果:
- 整体PEP发生率为6.6%.
- 印梅他辛组的PEP发病率为8.7%;迪克洛菲纳克组的PEP发病率为5.2% (p=0.057).
- 迪克洛菲纳克在预防PEP方面表现出更大的有效性,对于经过关节切除的天真乳头患者 (p=0.048).
结论:
- 在PPP预防方面,直肠迪克洛菲纳克可能比印莫他辛略有优势.
- 迪克洛菲纳克似乎对高风险患者特别有益,例如那些接受了膜切除手术的患者.
- 这突出了在特定患者群体中管理PEP的潜在新策略.
关键词:
复杂化 复杂化 复杂化 复杂化迪克洛芬雅克,胰腺炎内镜逆行性胆血管造机图 (cholangiopancreatography) 是一种内镜逆行式胆血管造机图.印度甲素 (Indomethacin) 是一种非类固醇抗炎药物 非类固醇抗炎药物更多相关视频
05:39Acupoint Needle-Embedding Combined with Ironing Therapy for Postoperative Pain After Anal Surgery
Published on: June 23, 2023
2.0K
07:36Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
Published on: December 23, 2022
1.9K
相关概念视频
Endoscopic Procedures V: ERCP
2.5K
Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...
Patient...
2.5K
Chronic Pancreatitis II: Collaborative Care
291
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
291
Acute Pancreatitis II: Clinical Manifestations and Management
705
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
705
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
413
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
413
