在肝细胞癌中由非编码RNA-蛋白相互作用网络驱动的自适应性耐药性机制
Yu Tian1, Kaobin Ouyang2, Hongsheng Wu3
1Science Research Center, Huizhou Central People's Hospital, Huizhou, Guangdong, China.
Critical reviews in oncology/hematology
|December 7, 2025
概括
非编码RNAs (ncRNAs) 和RNA结合蛋白 (RBPs) 是肝细胞癌 (HCC) 耐药性的关键调节剂. 针对这些ncRNA-RBP相互作用,为HCC的精密瘤学提供了有前途的治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 肝细胞癌 (HCC) 由于瘤异质性和治疗耐药性,具有显著的死亡率.
- 非编码RNAs (ncRNAs) 和RNA结合蛋白 (RBPs) 在调节复杂的细胞过程中起着至关重要的作用.
- 了解ncRNAs和RBPs之间的相互作用对于破译HCC进展和抵抗机制至关重要.
研究的目的:
- 审查了解ncRNAs和RBPs如何调节HCC中的关键途径的最新进展.
- 突出新的机制,包括RNA修饰和相分离,控制ncRNA-RBP相互作用.
- 探索向ncRNA-RBP轴的治疗潜力,用于HCC的精密瘤学.
主要方法:
- 关于ncRNAs,RBPs和HCC的最近机制学研究的文献综述.
- 对ncRNA-RBP相互作用特异性的新兴原则的分析.
- 讨论用于识别阻力相关网络的多主题和空间分析技术.
主要成果:
- ncRNAs,包括lncRNAs和circRNAs,与RBPs合作,以控制HCC中的ferroptosis,自,脂质代谢,免疫逃避和转录程序.
- RNA的化学修饰,结构元素和液-液相分离是ncRNA-RBP相互作用特异性的关键决定因素.
- 多omics和空间分析揭示了与HCC治疗耐药性相关的关键ncRNA-蛋白网络.
结论:
- 准ncRNA-RBP相互作用为HCC提供了可行的治疗机会.
- 了解这些调节回路可以指导生物标志物开发和个性化治疗策略.
- 这一框架支持肝细胞癌的精密瘤学的进步.
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