[慢性髓性白血病出现B-淋巴细胞转化后治疗未知初级的粘膜腺癌]
Yoshinori Oowada1, Tomoya Maeda2, Masanori Aoki1
1Clinical Laboratory, Saitama Medical University International Medical Center.
[Rinsho ketsueki] The Japanese journal of clinical hematology
|December 7, 2025
概括
二次性慢性髓性白血病 (CML) 是罕见的,但可能发生在癌症治疗后. 这一案例突出了一个患者通过向治疗和干细胞移植实现长期缓解,强调了癌症幸存者对CML风险的认识.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 二次性白血病,包括急性髓性白血病 (AML) 和骨髓质瘤 (MDS),是癌症治疗后已知的并发症.
- 慢性髓性白血病 (CML) 很少被报告为癌症治疗后的二次恶性瘤.
研究的目的:
- 在B淋巴细胞爆发期报告一种罕见的二次性CML病例.
- 讨论二次性CML的管理和长期结果,在一个有固体瘤病史和先前癌症治疗的患者.
主要方法:
- 一个50岁的男性被诊断患有二次性CML的病例报告.
- 治疗包括氨酸激酶抑制剂,高CVAD/MA化疗,全原造血干细胞移植和阿西米尼布治疗.
- 监测深层分子响应 (DMR).
主要成果:
- 患者获得了主要的分子反应,随后在异构造血细胞干细胞移植后维持了DMR.
- 长期的DMR在阿西米尼布治疗下持续了26个月.
- 该患者的二次CML是在治疗粘膜腺癌12年后发展的.
结论:
- 二次性CML虽然很少见,但可能发生在有癌症治疗史的患者中.
- 除了AML/MDS外,对CML风险的认识对于以前因癌症接受过治疗的患者至关重要.
- 有效的管理策略,包括向治疗和移植,可以导致持久的缓解.
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