多基因组揭示了膝关节协炎中肠关节轴的失调:来自中国两项骨关节炎研究的数据
Xiaoshuai Wang1,2, Yi Liu3,4, Ziying Sun5
1Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|December 7, 2025
概括
肠道微生物群不平衡与膝关节综合炎有关. 这项研究揭示了肠-关节轴,确定了微生物变化和TWEAK信号作为膝关节炎症的潜在治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 蛋白质组学是指蛋白质组学
- 骨关节炎研究 骨关节炎研究
背景情况:
- 肠道微生物群失调和免疫代谢障碍与膝关节综合炎有关.
- 肠道健康和膝关节炎症之间的潜在联系,称为肠-关节轴,需要进一步调查.
研究的目的:
- 在膝关节突炎中探索肠关节轴,使用集成的多omics分析.
- 为了确定与膝关节综合炎相关的微生物,代谢和蛋白质变化.
- 为了研究治疗干预的潜在的突目标.
主要方法:
- 在珍珠河骨关节炎队列 (PROC) 的便和血液样本上进行了综合的多组学分析 (元基因组学,代谢组学,蛋白质组学).
- 磁共振成像 (MRI) 用于膝盖突炎的识别.
- 同胞液蛋白质组学,组织学和体外实验,使用来自南京骨关节炎队列 (NOC) 的纤维细胞样同胞细胞 (FLS).
主要成果:
- 膝关节综合炎的病例显示,Firmicutes/Bacteroidetes (F/B) 比率有所增加.
- 微生物功能的变化 (氨酸和兰醇降解) 与特定代谢物和下调血相关.
- 在较高等级的突炎中观察到一个上调的TWEAK受体,而体外TWEAK暴露在FLS中降低了其受体的调节.
结论:
- 这项研究确定了膝关节综合炎的肠关节轴.
- 鉴定了与突炎相关的微生物和代谢特征.
- 揭示了TWEAK信号通路在突的改变,表明它是一个潜在的治疗目标.
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