可改变的生活方式因素和印度人肥胖的遗传风险
Emadeldin Hassanin1, Rakesh Kalapala2, Nitin Jagtap2
1Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Sur-Alzette, Belvaux, 4367, Luxembourg.
Scientific reports
|December 7, 2025
概括
保持健康的生活方式,包括体力活动和均衡的饮食,可以显著降低印度裔个体的肥胖风险,即使是那些对体重指数 (BMI) 有很高的遗传倾向的人. 这一发现强调了生活方式选择在减轻对肥胖的遗传易感性方面的力量.
科学领域:
- 遗传学和公共卫生
- 肥胖问题研究研究
- 生活方式 医学 医疗
背景情况:
- 肥胖是一种复杂的疾病,受遗传和环境因素的影响.
- 印度血统的个人具有独特的遗传倾向,并面临肥胖和相关代谢障碍的高风险.
- 了解遗传风险和生活方式之间的相互作用对于有效的肥胖预防策略至关重要.
研究的目的:
- 为了调查健康的生活方式和肥胖风险之间的关系,在一个高的多基因风险得分 (PRS) 身体质量指数 (BMI) 的印度血统的个人.
- 为了确定有利的生活方式是否可以抵消对肥胖的强烈遗传倾向.
主要方法:
- 分析了两个独立的队列 (英国生物银行和Wellytics-Asian Institute of Gastroenterology队列),包括印度血统的个人.
- 使用BMI-PRS的基因倾向的量化.
- 将生活方式行为 (体育活动,吸烟,饮食) 评估成综合评分 (有利与不利).
主要成果:
- 肥胖个体的BMI-PRS值明显高于非肥胖个体在两个队伍.
- 具有高遗传风险 (高BMI-PRS) 和不良生活方式的参与者患肥胖的几率最高.
- 相反,具有高遗传风险但生活方式有利的个体显示肥胖的几率降低.
结论:
- 持续坚持健康的生活方式与较低的肥胖风险有关,即使存在高遗传倾向.
- 生活方式干预可以有效地减轻印度裔个人对肥胖的遗传易感性.
- 公共卫生战略应强调健康的生活方式选择对于预防遗传风险人群肥胖的重要性.
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