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Updated: Jan 9, 2026

Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System
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Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System

Published on: April 11, 2025

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通过干扰NEMO-RIPK1-RIPK3相互作用,GADD45β抑制了RIPK3介导的NF-κB激活

Carmela Casale1, Alete Colella1, Miriam Cruoglio1

  • 1Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (CNR), Naples, Italy.

Cell death discovery
|December 7, 2025
PubMed
概括

增长阻断和DNA损伤诱导性β (GADD45β) 通过抑制RIPK3介导的NF-κB激活来调节亡. 这一发现揭示了GADD45β作为免疫反应的关键调节器,并表明对炎症性疾病的治疗潜力.

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