胚胎热操纵改善了早期肉中的微生物多样性,代谢途径和免疫力
Sadid Al Amaz1, Suman Poudel1, Md Ahosanul Haque1
1Department of Human Nutrition, Food and Animal Sciences, College of Tropical Agriculture and Human Resilience, University of Hawai'i at Manoa, AgSci 216, 1955 East-West Rd, Honolulu, HI, 96822, USA.
Scientific reports
|December 7, 2025
概括
胚胎热操纵 (TM) 增强了 brojler肠道微生物多样性,并预测了代谢途径. 这种早期的干预改善了与乳头免疫相关的基因表达,促进了更健康的肉.
科学领域:
- 禽畜科学 禽畜科学 禽畜科学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群在肉胃肠功能,新陈代谢和免疫力方面发挥着至关重要的作用.
- 调节早期肠道微生物群是家禽业的一个有前途的战略.
- 胚胎热操纵 (TM) 是一种可持续的肉生产方法,之前的研究表明对生长和免疫的影响.
研究的目的:
- 为了研究胚胎TM对早期脑内微生物群组成的影响.
- 分析预测的微生物代谢途径和与乳头免疫相关的基因表达.
- 了解TM如何影响早期发育期 brojler的肠道健康和免疫力.
主要方法:
- 肥沃的科布500只蛋接受了TM (38.5°C,55%的RH从ED12-18开始) 或控制化.
- 化后的小被安置在子里,包括控制组和TM组在内的治疗.
- 在第7天,第14天和第21天评估了Cecal微生物群组成,多样性指数,预测的代谢途径和ileal免疫基因表达.
主要成果:
- 在第7天,第14天和第21天,TM显著增加了微生物β多样性,并预测了代谢途径.
- 几种与免疫相关的基因 (例如IL10,IL12,TLR4) 的Ileal表达在第7天在TM组显着较低.
- 在第21天,TM改变了特定免疫基因 (例如IL4,IL6,TLR2A) 的表达,表明动态免疫调节.
结论:
- 胚胎TM显著增强肉的微生物多样性和预测的代谢途径.
- 在肉发育的早期阶段,TM积极调节结核免疫相关的基因表达.
- 这项研究强调TM是改善肉肠道健康和免疫力的有效策略.
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