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在HFpEF中,压力高血糖比率和身体脆弱性

Pasquale Mone^1,2, Klara Komici³, Germano Guerra³

¹Department of Medicine and Health Sciences "Vincenzo Tiberio", Universityof Molise, Campobasso, Italy. pasquale.mone@unimol.it.

Cardiovascular diabetology

|December 7, 2025

概括

较高的压力高血糖比率 (SHR) 表明脆弱的老年人患有心力衰竭与保留射出分数 (HFpEF) 的身体功能较差. 这表明与压力相关的失糖症有助于这一脆弱人群的功能衰退.

科学领域:

心脏病学心脏病学
内分泌学在内分泌学.
老年病的医生老年病的医生

背景情况:

压力高血糖,通过压力高血糖比率 (SHR) 测量,与不良的心血管结果有关.
在老年人中,心力衰竭与保存的射出分数 (HFpEF) 经常与高血糖和虚弱共存.
身体虚弱在机制上与失糖症和HFpEF有关.

研究的目的:

调查诊断为HFpEF的脆弱老年人中SHR和身体表现之间的关联.
为了确定与压力相关的高血糖是否会影响这个特定患者群体的身体功能.

主要方法:

一项前性观察性研究包括65岁以上的脆弱成年人,他们有HFpEF和认知障碍 (MoCA<26).
使用弗里德标准 (≥5个标准中的3个) 评估脆弱性.
用吸收血葡萄糖和HbA1c计算SHR;用步行速度测量身体功能.

主要成果:

204名参与者完成了这项研究.
与SHR ≤ 1 (0.72 m/s) 患者相比,SHR > 1的患者的步行速度显著降低 (0.65 m/s).
步行速度的差异在统计学上是显著的 (p=0.0004).

结论:

较高的SHR独立地与HFpEF的脆弱老年人身体功能较差有关.
与压力相关的失糖症可能会导致这个人群的功能下降.
在HFpEF患者中,SHR可以作为虚弱严重程度和心血管脆弱性的代谢标记.

关键词:

脆弱性脆弱性脆弱性步行速度步行速度心力衰竭与保存的喷射分数的心脏衰竭年龄较大的成年人.压力高血糖比率是压力高血糖比率.

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