同时发生的头和肺癌:影响和治疗管理时间
Dario Ebode1, France Truong2, Caroline Halimi3
1Department of Oto-Rhino-Laryngology Head and Neck Surgery, APHM, La Conception University Hospital, Aix-Marseille University, Marseille, France.
概括
同时患有头部和部状细胞癌 (HNSCC) 和肺癌的患者面临更长的诊断到治疗间隔 (DTI),影响生存率. 通过并发手术减少DTI可能会改善这些双癌患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 临床医学 临床医学
背景情况:
- 同时发生的头部和部状细胞癌 (HNSCC) 和肺癌带来了独特的临床挑战.
- 了解影响这些患者诊断到治疗间隔 (DTI) 和生存的因素对于改善护理至关重要.
研究的目的:
- 为了描述同时患有HNSCC和肺癌的患者.
- 评估DTI和治疗选择对双重HNSCC和肺癌患者的治疗结果的影响.
主要方法:
- 一个双中心的回顾性观察性研究,将43名同时患有HNSCC和肺癌的患者与单独患有HNSCC的匹配对照组进行比较.
- 使用多变量分析和卡普兰-梅尔生存率分析来评估DTI和整体生存率.
主要成果:
- 与对照组 (28天) 相比,同时患有癌症的患者的DTI显著更长 (中位数为43天).
- 同时患有癌症的患者的整体存活率明显较差 (中位数为17.8个月),而不是对照组 (56.5个月).
- 在同时治疗的癌症组中,主要是有严重吸烟史的男性患者,患有高级HNSCC阶段和早期肺癌.
结论:
- 长期的DTI与诊断为同时患有HNSCC和肺癌的患者的生存结果较差有关.
- 缩短DTI的策略,如并发支气管镜和内镜,需要进行调查以改善患者的生存率.
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