通过基因淘汰/淘汰策略改善对恶性瘤的CAR T细胞疗法:系统性审查
Amirali Karimi1, Sayedeh-Zahra Kazemi-Harikandei1, Sanam Alilou1
1School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Cancer cell international
|December 7, 2025
概括
在CAR T细胞中的基因编辑通过提高疗效和减少副作用来增强癌症治疗. 这一系统性审查确定了105个基因标,以提高CAR T细胞治疗结果.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物技术是生物技术.
背景情况:
- 化学抗原受体 (CAR) T细胞疗法在治疗血液和固体瘤方面面临着挑战.
- 基因编辑技术提供了潜在的改进,但缺乏对临床前和临床结果的全面审查.
研究的目的:
- 系统地审查基因编辑CAR T细胞的结果的临床前和临床研究.
- 识别可以被淘汰或被淘汰的基因 (KO/KD),以增强CAR T细胞治疗.
主要方法:
- 按照PRISMA 2020指南进行系统审查,并注册在PROSPERO (ID CRD42022320541) 上.
- 搜索了五个数据库 (PubMed,EMBASE,Cochrane图书馆,科学网,Clinicaltrials.gov) 搜索了关于CAR T细胞和KO/KD基因的研究.
- 包括241个记录 (193个动物,52个人类) 报告了105种蛋白质的KO/KD.
主要成果:
- 对105种蛋白质的基因编辑证明了五个关键的好处:使异性CAR产生,同时限制GVHD,增加CAR T细胞的疗效,减少副作用,限制CAR T细胞兄弟杀伤,并允许并发疗法.
- 人类研究表明,与血液恶性瘤相比,固体瘤的良好结果较少.
结论:
- 本综述强调了各种机制,以提高CAR T细胞治疗的有效性.
- 确定了105个候选基因用于未来的研究,并强调需要更多地关注固体瘤.
相关概念视频
01:27Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
02:49Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
02:57Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K