用于递送的口腔菌膜:使用透增强剂和聚合物的配方策略
Sandeep Karki1, Sahil Malhotra1, Muhammad Ijaz1
1School of Veterinary Medicine and Conway Institute, University College Dublin (UCD), Belfield, D04 V1W8, Ireland.
Drug delivery and translational research
|December 7, 2025
概括
口腔粘膜为递送提供了无针的替代方案,克服了酶降解和吸收不良等挑战. 配方策略提高的生物可用性,以改善系统性递送.
科学领域:
- 制药科学 制药科学
- 生物材料科学 生物材料科学
背景情况:
- 口腔和舌下粘膜是可行的系统性输送路径,避免了口服和注射形式的限制.
- 输送口腔菌的挑战包括唾液洗,酶降解和表皮屏障抵抗.
研究的目的:
- 审查通过口腔菌膜增强的生物可用性的配方策略.
- 突出纳米粒子集成膜的进步,以提高的稳定性和透性.
主要方法:
- 关于口腔粘菌输送系统的文献综述.
- 配方组件的分析:透增强剂 (PE),粘膜聚合物和多层膜架构.
- 专注于纳米粒子在片设计中的集成.
主要成果:
- 透增强剂,粘膜聚合物和多层薄膜是克服菌传递障碍的关键策略.
- 纳米粒子集成显示了增强稳定性和粘膜透性的前景.
- 患者遵守,转化潜力和监管因素对于临床进步至关重要.
结论:
- 口腔膜代表了对注射的有希望的,患者可以接受的替代方案.
- 先进的配方策略,特别是纳米粒子集成薄膜,对于成功的递送至关重要.
- 解决转化和监管方面的问题对于酸载荷的膜的临床成功至关重要.
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