在PHACS SMARTT研究中,周产期暴露于艾滋病毒并未感染的儿童的听力测量
Peter Torre1, Elham Sirag2, Paige L Williams3
1From the School of Speech, Language, and Hearing Sciences, San Diego State University, San Diego, California.
The Pediatric infectious disease journal
|December 8, 2025
概括
在子宫内抗逆转录病毒暴露没有显示出与未暴露于艾滋病毒的儿童的听力损失有一致的联系. 需要进一步的研究来了解暴露在抗逆转录病毒药物中的儿童对听力结果的潜在影响.
科学领域:
- 儿科健康 儿科健康
- 药理学 药理学 是一个学科.
- 听力学 听力学是指听力学.
背景情况:
- 关于宫内抗逆转录病毒 (ARV) 暴露对未感染艾滋病毒 (CHEU) 的儿童听力有毒影响的研究有限.
- 特定的ARVs,如诺福维尔二二醇烟酸 (TDF),三胺 (FTC),拉米武丁 (3TC),齐多武丁 (ZDV) 和阿塔萨纳维尔 (ATV) 已经引起了人们的关注.
研究的目的:
- 在5岁的CHEU中描述听力结果.
- 评估子宫内ARV暴露与听力结果之间的关联.
主要方法:
- 听力评估包括纯色度值和扭曲产品的音声排放 (DPOAEs) 在1078CHEU5岁时进行.
- 逻辑双项回归模型评估了母体ARV暴露与感官神经听力损失 (SNHL) 和不完整DPOAE反应风险之间的关系.
主要成果:
- 13%的CHEU提供了SNHL.
- 早期孕期暴露 (<13周) 显示不同ARV疗程的SNHL风险不同 (例如,TDF/FTC与ATV相比,ZDV/3TC没有ATV).
- 对风险的信心区间很宽,表明关联中的不确定性.
结论:
- 虽然在13%的CHEU中观察到SNHL,但在子宫内ARV暴露与SNHL或不完整的DPOAEs之间没有发现一致的关联.
- 进一步调查ARV暴露和CHEU的各种听证措施是有必要的.
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