慢性阻塞性肺病中自主神经系统功能障碍:机械学见解和治疗影响
Daohong Chen1, Zijing Zhou1, Ziyang Zhou1
1School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
自主神经系统 (ANS) 失调通过失衡交感和副交感活动,使慢性阻塞性肺病 (COPD) 恶化. 精确的ANS调制为COPD管理提供了新的治疗策略.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 慢性阻塞性肺病 (COPD) 是一种复杂的呼吸系统疾病.
- 自主神经系统 (ANS) 失调越来越多地被认为是COPD进展的一个因素.
研究的目的:
- 审查目前对COPD中ANS介导病理生理学的机制性见解.
- 探索针对COPD自主功能障碍的新型治疗策略.
主要方法:
- 临床前和临床研究的叙述性综述.
- 来自PubMed和Web of Science的研究分析,重点关注COPD中与ANS相关的途径.
- 整合性解释已发表的关于机制和疗法的证据.
主要成果:
- 美国神经神经系统的失衡 (低同情度,高寄同情度) 会加剧COPD病理.
- 胆固醇过活性会导致呼吸道收缩/粘液,同情性抑制会损害支气管扩张/免疫力.
- 自主功能障碍将COPD与心血管疾病和肺癌等并发症联系在一起.
结论:
- 精确调节ANS可塑性是一种COPD的变革性方法.
- 未来的研究应该集中在组合疗法和生物标志物驱动的分层.
- 针对ANS功能障碍的个性化干预可以减轻COPD的进展和并发症.
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