在交感刺激刺激期间,多发性硬化症成人的非活跃四肢血流调节受损
Sara R Sherman1, Natalia S Lima1, Robert W Motl1
1Integrative Physiology Laboratory, Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, Illinois, USA.
Physiological reports
|December 8, 2025
概括
患有多发性硬化症 (MS) 的人在运动时表现出外周血流调节受损,特别是当与轻度的同情刺激相结合时. 这表明自主功能障碍会影响MS患者的血管控制.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统功能 自主神经系统功能
- 神经学 神经学
背景情况:
- 多发性硬化症 (MS) 与身体能力的降低有关,部分原因是自主功能障碍.
- 在MS中,运动期间对外周血流的调节尚未完全理解.
研究的目的:
- 为了比较外围血管对动态握手运动的反应,在患有和没有多发性硬化症的个体中,有或没有下体负压 (LBNP).
- 为了研究MS中轻度交感刺激性压力期间的血管运动调节.
主要方法:
- 21名多发性硬化症患者和27名对照患者在15%和30%的最大自愿收缩 (MVC) 时进行了动态手握运动.
- 运动在-20 mmHg下部负压 (LBNP) 期间重复,以诱导轻度的交感刺激.
- 血压通过手指光电流学测量,并通过超声波评估关动脉血流量.
主要成果:
- 与对照人群相比,患有多发性硬化症的个体在基线和运动期间与LBNP相比,在不活跃的四肢中表现出前臂血管导电率的增加.
- 尽管有这些变化,但在不活动四肢的前臂血管导电性方面没有群体差异.
- 在LBNP期间,MS组观察到平均动脉压 (MAP) 的减弱增加.
结论:
- 患有多发性硬化症的人表现出血管运动调节受损,特别是在运动和交感刺激性压力相结合的情况下.
- 这些发现突出了与自主血管控制缺陷相关的MS体能减弱的潜在机制.
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