确定心血管干预后与肉类相关的死亡率的最佳肌肉表面积值
Otto Järvinen1, Juho Tynkkynen2, Iisa Lindström3
1Faculty of Medicine and Health Technology Tampere University Kalevantie 4 Tampere FI-33014 Finland Finnish Cardiovascular Research Centre Tampere Tampere Finland.
概括
肌区域 (PMA) 预测心血管手术后的死亡风险. 较低的PMA,表明肉,与长期死亡风险的增加线性相关,特别是低于-1.5.5的Z值.
科学领域:
- 心血管医学 心血管医学
- 老年病的医生 老年病的医生
- 麻症研究研究 麻症研究
背景情况:
- 肌区域 (PMA) 是已知与肉类相关的死亡率的预测因素.
- 对于PMA与长期死亡率之间的关联的确切性质以及是否存在特定的门,需要进一步调查.
研究的目的:
- 确定PMA与长期死亡率之间的关联是线性的还是非线性的.
- 根据PMA,确定一个潜在的临床值来定义患有高死亡风险的患者.
主要方法:
- 来自四组 (3893名患者) 接受心血管干预 (AAA,TAVI,TA,PAD) 的个人参与者数据的元分析.
- 聚合的脊柱曲线可视化了PMA与死亡率的关联.
- 考克斯模型和反变量元分析被用来结合危险比率.
- 结果在一个单独的队列中 (561名患者) 得到验证,该队列通过按摩器肌肉区域评估了sarcopenia.
主要成果:
- PMA显示与长期死亡率有显著的反向和线性关联 (p < 0.001).
- 肌肉质量低的患者 (PMA Z值≤-1.5) 的调整后死亡风险增加了1.6倍 (HR1.6,95%CI1.3-2.0).
- 这一发现在复制队列中是一致的 (HR 1.7,95% CI 1.0-2.82).
结论:
- 随着心血管干预后PMA的下降,长期死亡风险线性增加.
- 低于-1.5的PMA Z值标明了患者的死亡风险持续升高,而不考虑其他因素.
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