个性化参考间隔与间接估计的人口基参考间隔用于血液学测量和测量
Ozlem Demirelce1, Berrin Bercik Inal2, Abdurrahman Coşkun3
1Department of Medical Biochemistry, University of Health Sciences, Göztepe Training and Research Hospital, Istanbul, Turkey.
International journal of laboratory hematology
|December 8, 2025
概括
个性化参考间隔 (prRI) 提供了比基于人口的参考间隔 (popRI) 更准确的完整血清 (CBC) 结果的解释. 这项研究表明,对于各种CBC参数,prRI和popRI之间存在显著差异.
科学领域:
- 临床实验室科学 临床实验室科学
- 血液学 血液学 血液学
- 生物统计学 生物统计学
背景情况:
- 实验室数据的准确解释依赖于可靠的参考间隔 (RIs).
- 基于人口的参考间隔 (popRIs) 是标准的,但从个人数据中获得的个性化参考间隔 (prRIs) 提供了更好的准确性.
- 这项研究比较了prRI与popRI用于常见的血液学参数.
研究的目的:
- 为了估计常见的血液学参数的个性化参考间隔 (prRI).
- 将这些prRI与基于人口的参考区间 (popRI) 进行比较.
- 评估prRIs对血液学临床决策的有用性.
主要方法:
- 基于人群的参考间隔 (popRIs) 用患者实验室数据估计了17个全血细胞计 (CBC) 亚参数.
- 针对相同的参数,通过预测间隔模型,使用200名健康个体的纵向数据计算了个性化参考间隔 (prRI).
- 参考区间指数 (RII) 被计算为prRI范围与popRI范围的比值,用于每个测量值.
主要成果:
- 针对CBC参数的个性化参考间隔 (prRI) 与基于人口的参考间隔 (popRI) 相比显示出显著差异.
- 基准区间指数 (RII) 的中位数从0.41的乙酸氨基细胞到2.97的血小板分布宽度 (PDW).
- 这些发现表明,个体RI如何偏离人口规范的变异性.
结论:
- 对CBC参数的个性化参考区间 (prRI) 与相应的基于人口的参考区间 (popRI) 明显不同.
- 建议使用prRIs来更准确地解释患者的CBC结果.
- 实施prRI可以提高血液学临床决策的准确性.
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