环境因素影响成年人喘中的微生物组:新兴的机制性见解
Mário Morais-Almeida1, Raquel Baptista-Pestana
1Allergy Centre, CUF Descobertas Hospital, Lisbon, Portugal.
Current opinion in allergy and clinical immunology
|December 8, 2025
概括
肠肺轴和微生物组显著影响喘. 环境因素改变了微生物组,影响了免疫反应和喘严重程度,突出了基于微生物组的治疗需求.
科学领域:
- 肺部医学 肺部医学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 喘是一种复杂的疾病,受宿主环境相互作用的影响.
- 微生物群,特别是在肠道和呼吸道,在喘病理生理学中起着至关重要的作用.
- 污染,饮食和气候等环境暴露对喘的发展和表达有重大影响.
研究的目的:
- 审查环境暴露如何重塑微生物生态系统.
- 为了检查成人喘患者免疫反应的重编程.
- 强调微生物组研究在喘中的临床转化.
主要方法:
- 综述多学科研究.
- 大规模队列的分析.
- 检查孟德尔的随机化研究.
主要成果:
- 肠肺轴是喘结果的关键调节器.
- 由蛋白质细菌特征的呼吸道失调与喘控制不良和类固醇耐药性相关.
- 微生物代谢物,如短链脂肪酸,可以恢复免疫平衡,挑战喘的传统炎症观点.
结论:
- 微生物组对于理解喘至关重要.
- 微生物组信息的生物标志物和干预措施对于成人喘的精准医学至关重要.
- 需要进一步的干预研究才能将研究结果转化为临床实践.
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