移植后的De novo恶性瘤发展:在临床实践中管理风险和结果
Amil Huseynov1, Sevim Nuran Kuşlu Çiçek2
1Department of Transplantation, Beykoz University Faculty of Medicine, İstanbul, Türkiye.
Turkish journal of surgery
|December 8, 2025
概括
新生恶性瘤发生在3.6%的脏移植接受者中. 高龄是显著的风险因素,突出了针对性查和管理策略在这个脆弱的人群的需要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 在瘤学瘤学.
- 移植免疫学 移植免疫学
背景情况:
- 新生恶性瘤是移植后的严重并发症,通常与长期免疫抑制有关.
- 了解这些癌症的发病率和风险因素对于改善患者的治疗结果至关重要.
研究的目的:
- 评估移植患者中新发恶性瘤的发病率,风险因素和临床结果.
- 确定与恶性瘤发展相关的特定患者特征和管理策略.
主要方法:
- 在1200名移植患者 (2016-2023) 的回顾性队列研究中.
- 对患者人口统计,并发病,免疫抑制疗法和恶性瘤状况的分析.
- 卡普兰-梅尔分析和日志等级测试用于生存评估.
主要成果:
- 在3.6%的接受者中诊断出了新的恶性瘤.
- 非黑色素瘤性皮肤癌和移植后的淋巴增殖性疾病是最常见的.
- 接受者年龄较大是一个显著的风险因素 (HR=1.03/年,p=0.025).
结论:
- 在移植接受者,尤其是老年人中,de novo恶性瘤是一个重大问题.
- 定期查,生活方式干预和量身定制的免疫抑制是至关重要的.
- 积极主动管理可以帮助减轻风险并改善长期生存.
相关概念视频
Kidney Transplant III: Nursing Management
294
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
294
Kidney Transplant II: Surgical Procedure
289
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
289
Kidney Transplant I: Introduction
310
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
310
Acute Kidney Injury IV: Diagnostic Studies and Prevention
244
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
244
Tissue Transplantation
870
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
870
Acute Kidney Injury III: Clinical Manifestations
778
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
778


