内皮激活和压力指数预测了接受CRRT的患者28天死亡率
Jinjin Hu1, Junjun Wei1, Weiwei Feng1
1Hemopurification Center, Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, China.
Biomolecules & biomedicine
|December 8, 2025
概括
内皮激活和压力指数 (EASIX) 是接受连续置换疗法 (CRRT) 的患者死亡率的重要预测指标. 较高的EASIX分数与这一群体28天全因死亡风险增加有关.
科学领域:
- 关键护理医学 关键护理医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物标志物 生物标志物
背景情况:
- 内皮激活和压力指数 (EASIX) 是各种疾病的已知的预后指标.
- 在接受连续置换疗法 (CRRT) 的患者中,其预测价值仍未得到充分研究.
研究的目的:
- 调查EASIX与预后之间的关联,特别是28天全因死亡率,在接受CRRT的重症患者中.
- 评估EASIX增强现有预后模型 (如SOFA) 的潜力.
主要方法:
- 从MIMIC-IV数据库对2873名接受CRRT的ICU患者的回顾性分析.
- 使用了Kaplan-Meier生存分析,Cox比例危险回归和受限立方线 (RCS) 分析.
- 计算了EASIX分数,进行了log2转换,并在四分位数中进行了分析.
主要成果:
- 较高的EASIX分数与较低的28天生存率有显著的联系 (日志排名p < 0.001).
- 经调整的考克斯回归显示,EASIX与28天全因死亡率独立相关 (HR:1.066,p = 0.001).
- 与单独使用SOFA相比,SOFA+EASIX模型显示出更好的预测性能 (AUC 0.694).
结论:
- 在接受CRRT的患者中,EASIX是死亡的独立预测因子.
- 在这种患者群体中,EASIX可能会提高SOFA得分的预后准确性.
- 需要进一步的前性研究来确认EASIX的治疗和预后意义.
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