在异形性炎症性肌肉病变中的并发症:基于人群的关于风险亚组的证据和对护理提供的影响
Maria Emilia Romero Noboa1, Irakli Tskhakaia, James S Andrews
1Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Current opinion in rheumatology
|December 8, 2025
概括
异常性炎症性肌肉病变 (IIM) 增加心血管事件,神经认知障碍和骨质损失的风险. 早期识别和多学科护理对于管理IIM患者中这些普遍的并发症至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 神经学 神经学
- 内分泌学 在内分泌学.
背景情况:
- 异形性炎症性肌肉病 (IIM) 与显著的非肌肉健康问题有关.
- 了解这些并发病的流行病学对于患者管理至关重要.
研究的目的:
- 综合最近基于人群的关于IIM中关键并发症的数据.
- 专注于动脉样性心血管疾病 (ASCVD),静脉血栓塞栓症 (VTE),精神/神经认知障碍和骨健康.
主要方法:
- 对最近基于人口的流行病学数据的审查.
- 综合与IIM并发症相关的发现.
主要成果:
- IIM患者面临与炎症,不活动和治疗相关的ASCVD和VTE风险增加了一倍.
- 抗HMGCR免疫媒介性瘤性肌肉病 (IMNM) 需要特定的脂质障碍症管理.
- 精神病,神经认知和骨健康问题 (骨质疏松症/骨质疏松症) 是常见的,在IIM中经常被忽视,特别是在包容体肌炎 (IBM) 中.
结论:
- 心血管,精神/神经认知和骨健康问题在IIM中非常普遍,而且诊断不足.
- 为了管理这些并发病,必须采取多学科的方法.
- 需要进一步的研究,以适应IIM患者的查和风险分层工具.
相关概念视频
Inflammatory Bowel Disease II: Crohn's Disease
925
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
925
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
617
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
617
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
448
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
448
Disorders of the Skeletal Muscle
1.7K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
1.7K
Myocarditis III: Medical Management
162
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
162
Inflammatory Bowel Disease I: Ulcerative Colitis
862
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
862


