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Updated: Jan 9, 2026

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

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通过尼古拉斯循环演化合成循环酸硫酸盐

Iaroslav A Kutuzov1, Ekaterina A Khmelevskaya1, Alexander F Khlebnikov1

  • 1Institute of Chemistry, Saint Petersburg State University (SPbU), Saint Petersburg 199034, Russia. n.danilkina@spbu.ru.

Organic & biomolecular chemistry
|December 8, 2025
PubMed
概括

尼古拉斯循环化提供了一个简单的路径,以循环octyne-sulfamates为应变促进的亚酸-酸循环添加 (SPAAC) 反应. 与融合的变种被证明是不稳定的,与它们的单环对应物不同.

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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