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下一代益生菌在过敏治疗中:科学证据和临床应用
Vatan Chaudhary1, Atul Pratap Singh1, Himanchal Sharma1
1Department of Pharmacy, IIMT University, Meerut, 250001, India.
Anti-inflammatory & anti-allergy agents in medicinal chemistry
|December 8, 2025
概括
益生菌,包括传统和下一代菌株,通过调节免疫反应和肠道屏障功能,在管理过敏疾病方面表现有前途. 使用微生物组分析和人工智能的个性化方法是过敏免疫治疗的未来方向.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 在全球范围内,过敏性疾病正在增加,与Th1/Th2不平衡和屏障功能障碍等免疫失调有关.
- 人们越来越认识到肠道微生物组在免疫调节中的作用,这引发了对益生菌疗法的兴趣.
- 益生菌,即带来健康益处的活微生物,具有免疫调节和肠道屏障恢复的潜力.
研究的目的:
- 审查传统和下一代益生菌在管理过敏疾病方面的治疗潜力.
- 探索益生菌影响免疫反应和肠道屏障功能的机制.
- 确定基于益生菌的过敏免疫疗法的挑战和未来机会.
主要方法:
- 对益生菌和过敏性疾病研究的文献综述.
- 分析涉及Treg分化,细胞因子调节和SCFA生产的机制.
- 评估下一代益生菌 (NGP) 和它们的特定抗炎化合物,如PSA.
主要成果:
- 传统的益生菌 (Lactobacillus,Bifidobacterium) 通过促进Tregs和产生抗炎细胞因子来减少过敏炎症.
- 益生菌增强粘膜屏障功能,并通过SCFA如丁酸盐恢复微生物平衡.
- NGPs (Akkermansia, Faecalibacterium) 提供有针对性的作用,分泌PSA等代谢物以调节免疫细胞并改善屏障完整性.
结论:
- 益生菌在通过各种免疫调节和障碍增强机制来管理过敏疾病方面显示出显著的潜力.
- 菌株特异性,剂量和安全性是益生菌有效性和应用的关键考虑因素.
- 未来的研究方向包括个性化微生物组分析,合成生物学和人工智能用于先进的过敏免疫疗法.
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