日本儿童慢性功能性便秘的药使用模式:一项纵向描述性研究
Takenori Akaike1,2, Toshiki Fukasawa1, Takanori Yanai1
1Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan.
概括
氧化是日本儿童便秘的主要药,聚乙烯甘醇 (PEG) 4000现在排在第二位. 2019年PEG 4000的引入减少了其他常规治疗的使用.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 药理疗研究 药理疗研究
- 现实世界 证据研究 实证研究
背景情况:
- 慢性功能性便秘 (CFC) 影响全球许多儿童.
- 了解药物治疗模式对于有效的儿科便秘管理至关重要.
- 2019年在日本引入聚乙烯甘醇 (PEG) 4000,促使治疗策略发生了转变.
研究的目的:
- 分析日本儿科慢性功能性便秘 (CFC) 的现实世界药物治疗趋势.
- 评估聚乙烯糖醇 (PEG) 4000市场引入对药处方模式的影响.
- 根据患者的人口统计和临床因素来识别药物使用的变化.
主要方法:
- 一项使用日本医疗保险索赔数据库的纵向描述性研究.
- 纳入标准:年龄在0-14岁的儿童,有便秘诊断和≥5天的药处方.
- 数据分析包括基线特征,12个月的治疗轨迹以及按性别,年龄和机构类型的子组分析.
主要成果:
- 在166,808名符合条件的儿童中,氧化是最常被处方的药 (31.0%),其次是PEG 4000 (19.9%).
- 2019年PEG 4000的引入与其他常规药的处方减少有关.
- 药的选择因年龄而异,PEG 4000,麦芽提取物和乳糖在较小的儿童中更为常见,而Kampo药在较大的儿童中更为常见.
结论:
- 氧化仍然是日本儿科CFC的主要药,而PEG 4000是第二常见的.
- 随着PEG 4000的可用性,人们对较旧的常规药的依赖减少了.
- 研究结果支持在临床实践中针对儿童便秘的个性化药物治疗方法.
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