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Updated: Jan 9, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
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在严重的败血症期间,BDKRB1的激活会诱导中性粒细胞的CXCR2脱敏,并加剧疾病的严重程度

Raquel Duque do Nascimento Arifa1,2, Carolina Braga Resende Mascarenhas1, Lívia Caroline Resende Rossi1

  • 1Laboratory of Microorganism-Host Interaction, Department of Microbiology, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

JCI insight
|December 8, 2025
PubMed
概括

布拉迪基宁B1受体 (BDKRB1) 在败血症引起的中性粒细胞功能障碍中起着关键作用. 抑制BDKRB1可以改善细菌清除,并在败血症模型中增强抗生素疗效.

关键词:
细菌感染 细菌感染细胞迁移/粘附情况炎症 炎症是一种炎症.微生物学 微生物学中性粒细胞中的中性粒细胞.

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