生物器官年龄与社区人口的慢性疾病风险有关
Celina S Liu1, Wan-Jin Yeo1,2, Aditya Surapaneni1
1Division of Precision Medicine, Department of Medicine, New York University, New York, New York, USA.
JCI insight
|December 8, 2025
概括
器官生物年龄比时间年龄更好地预测健康风险. 较老的器官年龄与癌症,心脏病和死亡的风险增加有关,有助于识别健康风险.
科学领域:
- 老年学是指老年学的学科.
- 生物标志物 生物标志物
- 蛋白质组学是指蛋白质组学.
背景情况:
- 时间学年龄是健康恶化的有限预测因素.
- 特定器官的生物年龄可以提供更精确的风险评估.
- 了解器官衰老对于积极的健康管理至关重要.
研究的目的:
- 在一个大型社区群体中调查器官特定的衰老模式.
- 评估生物器官年龄与不良健康结果之间的关联.
- 根据器官衰老概况识别出不同的患者表型.
主要方法:
- 11个器官的估计生物年龄,使用基于循环蛋白的模型,对11,757名社区动脉样硬化风险 (ARIC) 研究参与者进行了估计.
- 分析了器官年龄和健康结果之间的关联,并根据时间年龄进行调整.
- 利用等级聚合集群来定义基于器官年龄的患者表型.
主要成果:
- 较老的器官年龄显著与相关不良健康结果的风险增加有关,独立于时间上的年龄.
- 具体的例子包括与冠心病 (CHD) 相关的老动脉/心脏和老肺与肺癌相关的老肺.
- 出现了三种患者表型:老年器官,正常/略老年器官和年轻器官",老年器官"组显示出更高的癌症,死亡,末期脏病,心脏病,心力衰竭,感染和中风风险.
结论:
- 蛋白质体器官衰老特征与多种不良健康结果有显著的关联.
- 生物器官年龄是一个有价值的工具,用于识别患有严重健康恶化的风险较高的人.
- 这种方法对早期健康风险识别和个性化医疗具有前景.
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