关于炎症指数与性结肠炎疾病活动之间的相关性研究
Zhang Chenfei1, Zubiyan Ainiwaer1, Huang Xiaoling1
1Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, Xinjiang Uygur Autonomous Region, People's Republic of China.
International journal of general medicine
|December 8, 2025
概括
系统性免疫炎症指数 (SII) 和其他炎症标志物在性结肠炎 (UC) 患者中升高,与疾病活性相关. 中性粒细胞百分比-白蛋白比率 (NPAR) 显示了活性和严重UC的最高预测值.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病.
- 准确评估UC疾病活动和严重程度对于有效管理至关重要.
- 需要非侵入性生物标志物来补充现有的诊断工具.
研究的目的:
- 研究UC患者的全身免疫炎症指数 (SII) 水平.
- 评估SII和其他炎症指数与UC疾病活性和严重性的关系.
- 评估这些标志物对活跃和严重UC的预测值.
主要方法:
- 分析了616名UC患者和211名健康对照的队列.
- 使用修改后的梅奥得分来评估疾病活动.
- 包括SII,NLR,PLR和NPAR在内的炎症指数在使用斯皮尔曼相关性和ROC曲线分析的组之间进行了比较.
主要成果:
- 与对照组相比,UC患者的SII,NLR,PLR和NPAR显著增加.
- 这些炎症指数随着UC疾病严重程度的增加而增加.
- 对活跃和严重UC (AUC=0.854) 的NPAR显示了最高的预测效果.
结论:
- SII和其他炎症指数作为UC的有价值的非侵入性生物标志物.
- 这些标志物有效地评估UC疾病的活性和严重程度.
- NPAR是一个特别有前途的生物标志物,用于预测活跃和严重的UC.
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