在中等高度的血红蛋白质量和血液体积:为临床使用建立瘦身体重调整的参考值
Husain Y Alkhaldy1,2, Meshal M Alqahtani3, Mahdi S Al Amri4
1Central Labs, King Khalid University, Alqura'a, Abha, P.O. Box 960, Saudi Arabia.
International journal of general medicine
|December 8, 2025
概括
生活在中等海拔地区会增加血液体积 (BV) 和红细胞体积 (RBCV),因为红细胞质量更高. 这项研究表明,用于临床用途,BV和血红蛋白质量调整为瘦体质量的参考范围.
科学领域:
- 生理学 生理学 生理学
- 高度医学 高度医学
背景情况:
- 高海拔生活会改变血液组成,增加红细胞体积 (RBCV) 和减少血体积 (PV).
- 这些变化使血红蛋白 (Hb) 和血红素 (Hct) 水平的解释变得复杂.
- 对血液体积 (BV) 和血红蛋白质量 (Hbmass) 的准确评估对于中等海拔人口的临床实践至关重要.
研究的目的:
- 为了评估血液体积 (BV),红细胞体积 (RBCV),血体积 (PV) 和血红蛋白质量 (Hbmass) 在中等高度居民.
- 为了获得这些参数的参考范围,调整为瘦体质量 (LBM),用于临床应用.
- 了解适应中等高度的生理适应.
主要方法:
- 招募了158名中等海拔居民 (2250米) 和40名海平面控制人员.
- 使用一氧化碳再呼吸来确定血液体积和Hbmass.
- 通过双能量X射线吸收计量量化瘦体质量 (LBM).
主要成果:
- 与对照人群相比,中等高度的男性在正常化至LBM时显著增加了BV,RBCV和Hbmass.
- 当调整为LBM时,RBCV和Hbmass的性别差异消失了,而女性由于增加的PV而具有更高的BV.
- 与对照组相比,高海拔居民的RBCV较高,PV较低.
结论:
- 中等高度与血液体积增加有关,主要是由于红细胞体积更高.
- 在中等海拔地区的居民中,RBCV升高解释了更高的血红蛋白水平.
- 建议用于临床使用的血液体积和Hbmass的建议参考范围,调整为LBM.
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