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针对微生物介导的巨细胞教育:癌症免疫疗法的新范式

Rongwei Xu¹, Xinyuan Zhao¹, Xu Chen¹

¹Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou 510280, Guangdong, China.

Biomaterials research

|December 8, 2025

概括

微生物在瘤微环境 (TME) 中显著影响瘤相关巨细胞 (TAM),影响癌症进展和免疫疗法的有效性. 针对这些微生物-TAM相互作用提供了新的策略,以增强癌症治疗和克服耐药性.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
微生物学微生物学

背景情况:

瘤微环境 (TME) 是一个复杂的系统,瘤细胞,免疫细胞和微生物相互作用,影响癌症的进展和治疗结果.
瘤相关巨细胞 (TAMs) 是TME的关键参与者,表现出可塑性和根据瘤和微生物信号调整功能.
微生物 (细菌,病毒,真菌) 和它们的代谢物影响TAM极化,代谢和免疫调节,影响瘤生长和免疫逃避.

研究的目的:

审查微生物塑造TAM反应的机制,特别是在癌症免疫治疗的背景下.
探索针对微生物-TAM相互作用以增强抗瘤免疫力的新兴治疗策略.

主要方法:

文献综述专注于微生物,TAM和癌症之间的相互作用.
通过微生物组成部分调节TAM生物学机制的分析.
检查利用微生物-TAM轴调节的新型治疗方法.

主要成果:

微生物信号极大地影响TAM功能,包括两极化和新陈代谢,从而影响瘤进展和免疫逃避.
新兴的策略涉及工程微生物,瘤病毒和微生物纳米材料来重新编程TAM以改善抗瘤反应.
向微生物-TAM轴显示了提高癌症免疫疗法的有效性和克服治疗耐药性的潜力.

结论:

微生物-TAM轴是癌症进展和对免疫疗法的反应的关键决定因素.
针对这一轴的创新治疗策略有望为彻底改变癌症治疗带来革命.
为了成功的临床转化,需要解决异质性和机械复杂性等挑战.

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